“Our goal is to revisit the argument of tumor cell origin and to provide a general hypothesis that genomic mutability and essentially all hallmarks of cancer, including the Warburg effect, can be linked to impaired respiration and energy metabolism. In brief, damage to cellular respiration precedes and underlies the genome instability that accompanies tumor development. Once established, genome instability contributes to further respiratory impairment, genome mutability, and tumor progression. In other words, effects become causes. This hypothesis is based on evidence that nuclear genome integrity is largely dependent on mitochondrial energy homeostasis and that all cells require a constant level of usable energy to maintain viability. While Warburg recognized the centrality of impaired respiration in the origin of cancer, he did not link this phenomenon to what are now recognized as the hallmarks of cancer. We review evidence that make these linkages and expand Warburg’s ideas on how impaired energy metabolism can be exploited for tumor management and prevention.”
The central theme of the paper is to establish the METABOLIC origin of cancer—establishing the fact this THIS is the primary *cause* of cancer, and that all the genetic mutations (and other hallmarks of cancer) are the downstream *effects* of metabolic dysfunction.
This is how you solve the riddle of the oncogenic paradox.
Cancer can be initiated by such a wide range of triggers (from viruses and radiation to inflammation and chemicals) because those things all damage cellular respiration. Once the metabolism is disrupted, things get weird.
(This is also why Nasha Winters says: “The genetic mutations considered by conventional medicine as the root causes of cancer are, in fact, modifiable by epigenetic factors. Indeed, it is well established that genetics is the cause of only 5-10 percent of cancers and most of these genes encode proteins that impact mitochondrial respiration. It is mitochondrial damage that causes cancer, not the genes. If the inherited cancer gene does not damage mitochondria, cancer will not occur.”)
Check out the journal article for a compelling overview of the linkages between energy metabolism and all the hallmarks of cancer (like uncontrolled growth, evasion of programmed cell death, and tissue invasion and metastasis).
Again, why does this matter? (I’m well aware of the fact that I’m repeating myself.)
Because, when we identify the origins of cancer as METABOLIC in nature (rather than genetic), we focus our therapeutic protocols on getting our energy metabolism back in order.
Might not sound like a big deal, but it is.
Here’s how they put it: “Is it genomic instability or is it impaired energy metabolism that is primarily responsible for the origin of cancer? This is more than an academic question, as the answer will impact approaches to cancer management and prevention. Metabolic studies in a variety of human cancers previously showed that loss of mitochondrial function preceded the appearance of malignancy and aerobic glycolysis . However, the general view over the last 50 years has been that gene mutations and chromosomal abnormalities underlie most aspects of tumor initiation and progression including the Warburg effect and impaired respiratory function. The gene theory of cancer would argue that mitochondrial dysfunction is an effect rather than a cause of cancer, whereas the metabolic impairment theory would argue the reverse. If gene mutations are the primary cause of cancer then the disease can be considered etiologically complicated requiring multiple solutions for management and prevention. This comes from findings that the numbers and types of mutations differ markedly among and within different types of tumors. If, on the other hand, impaired energy metabolism is primarily responsible for cancer, then most cancers can be considered a type of metabolic disease requiring fewer and less complicated solutions.”
P.S. Seyfried provides the scientific framework for understanding the metabolic ORIGINS of cancer. Nasha Winters provides a comprehensive handbook (The Metabolic Approach to Cancer) on how to approach your therapy given the metabolic origins.